In Vitro Antibacterial Effects Of Selective Histaminic Receptor Type 2 Blockers: A Novel Study
نویسنده
چکیده
Selective antihistamine receptor type 2 blockers are widely used for treatment of peptic ulcer, these drugs are famotidine,cimetidine,nizatidine and ranitidine and because many nonantibiot ics agents have antibacterial activity so this study aimed to evaluate the antibacterial effects of selective H2 blockers. Tewnty two of bacterial strains were slected 5 Staphylococcus aureus,5 Escherichia coli,6 Pseudomonas aeruginosa and (6)Klebsiella pneumoniae. The drug's effects determined by Agar disc diffusion and Agar well diffusion methods,then evaluation done through measurment of zone of inhibition and minimal inhibitory concentration(MIC). Results showed that cimetidine and ranitidine have insignificat and negligable antibacterial effects, while famotidine have significant antibacterial effects against Escherichia coli (MIC8mg/ml and inhibition zone25mm) and moderately against Staphylococcus aureus. In conclusion famotidine have significant antibacterial activity specially against Escherichia coli.
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